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. 2019 Nov 13;10:1144. doi: 10.3389/fgene.2019.01144

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Copyright © 2019 de Carvalho, de Morais, Vieira, Rabelo, Llerena, Gonzalez and de Vasconcelos

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The variants affect the expression of miRNAs in patients with RASopathies. (A) Homozygous rs2155248 variant (G T-rev C A) in hsa-miR-1304-3p in patients P2, P3, P4, and P5, genotyped as AA; (B) homozygous rs2155248 variant (C G) in hsa-miR-146a-3p, found in all patients genotyped as GG; (C) heterozygous rs11614913 variant (C T) in hsa-miR-196a-2-3p in patient P3, genotyped as CT; (D) heterozygous rs3746444 variant (A G) in hsa-miR-499a-3p in patients P1, P3, and P5, genotyped as AG; (E) heterozygous rs3746444 variant (T C) in hsa-miR-499b-5p in patients P1, P3, and P5 genotyped as TC. The other referenced patients were genotyped as homozygous for the reference allele of the variant. The yellow and green bars represent the relative expression of miRNAs with and without variants, respectively. Means with the same lowercase letter are not significantly different from each other by Tukey test (P > 0.05).