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. 2019 Nov 13;10:1324. doi: 10.3389/fphar.2019.01324

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Copyright © 2019 Shi, Luo, Fang, Liu, Rao, Liu and Zeng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipopolysaccharide (LPS) administration acutely induced depression-like behavior. (A) Mice, the immobility time of the mice was prolonged in LPS group, compared with the control group (208.50 ± 15.90 vs 178.24 ± 7.62, N = 6 vs 5) (P 0.05), with 2 weeks of prior Xiaoyao Pills (XYW) administration (LPS + XYW), exhibited significantly lower immobility in the tail suspension test (208.50 ± 15.90 vs 186.38 ± 19.96, N = 6) (P 0.05) (Mann-Whitney test). (B) Mice, the immobility time of the mice was prolonged in LPS group, compared with the control group (143.39 ± 12.67 vs 121.55 ± 13.92, N = 6) (P 0.05), with 2 weeks of prior XYW administration (LPS + XYW), demonstrated significantly lower immobility in the forced swim test (143.39 ± 12.67 vs 93.56 ± 41.73, N = 6) (P 0.05) (t-test). (C, D) Rats, exposed to LPS exhibited significantly less distance travelled (558.75 ± 348.28 vs 1502.50 ± 303.73 (control) vs 1141.25 ± 156.79 (sham), N = 8) (P 0.05) and fewer number of vertical movements than the control and sham groups (4.88 ± 1.81 vs 14.00 ± 4.47 (control)vs 8.25 ± 1.91 (sham), N = 8) (P 0.05), with 2 weeks of prior XYW administration (LPS + XYW), exhibited a significantly higher distance travelled (558.75 ± 348.28 vs 945.00 ± 561.12 (0.93 g/kg) vs 1193.75 ± 204.80 (1.86 g/kg), N = 8) and times of vertical movement (4.88 ± 1.81 vs 8.25 ± 4.92 (0.93 g/kg) vs 9.63 ± 3.93 (1.86 g/kg), N = 8) (P 0.01) (t-test). (E) Rats, the LPS group exhibited a significantly lower comb time than the control and sham groups (37.88 ± 9.22 vs 85.50 ± 30.44 (control) vs 83.00 ± 40.62 (sham), N = 8) (P 0.05), with 2 weeks of prior XYW administration (LPS + XYW), exhibited a significantly longer time of combing (37.88 ± 9.22 vs 56.75 ± 13.77 (0.93 g/kg) vs 66.00 ± 22.90 (1.86 g/kg), N = 8) (n = 8, P 0.01) (Mann-Whitney test). (F) Rats, exposed to LPS exhibited a significantly lower saccharin preference than the control and sham groups [83.36 ± 10.72 vs 93.18 ± 3.44 (control) vs 93.25 ± 3.23 (sham), N = 8] (P 0.05), with 2 weeks of prior XYW administration (LPS + XYW), exhibited a significantly higher sucrose preference (83.36 ± 10.72 vs 93.62 ± 1.77 (0.93 g/kg) vs 93.91 ± 3.55 (1.86 g/kg), N = 8 vs 7 vs 8) (P 0.05) (t-test). (G) Rats, the LPS group exhibited a significantly longer latency to feed than the control and sham groups (158.00 ± 76.04 vs 64.63 ± 41.43 (control) vs 80.00 ± 39.14 (sham), N = 8) (P 0.05), with 2 weeks of prior XYW administration (LPS + XYW), exhibited a significantly shorter latency to feed (158.00 ± 76.04 vs 156.75 ± 108.30 (0.93 g/kg) vs 71.50 ± 27.40 (1.86 g/kg), N = 8) (n ≥ 7, P 0.05) (Mann-Whitney test). Compared with the control group, ^#P < 0.05,^##P < 0.01. Compared with the LPS group, *P < 0.05,**P < 0.01.

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