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. 2019 Nov 13;10:1324. doi: 10.3389/fphar.2019.01324

Figure 4.

Figure 4

LPS administration acutely induced inflammation in different brain regions. (A) Mice, LPS administration resulted in significantly lower levels of 5-HT in the hippocampus and cortex than in control groups (cortex:35.40 ± 3.29 vs 62.70 ± 5.36, N = 5, hippocampus:41.27 ± 9.84 vs 70.85 ± 21.88, N = 5) (P 0.05 or P 0.01). with 2 weeks of prior XYW administration (LPS + XYW), exhibited significantly higher levels of 5-hydroxytryptamine (5-HT) in different regions (cortex: 35.40 ± 3.29 vs 66.67 ± 12.55, N = 5, hippocampus: 41.27 ± 9.84 vs 86.91 ± 31.91, N = 5) (P 0.05 or P 0.01) (A1-2: t-test). (B) Mice, LPS administration resulted in significantly increased level of IDO in cortex than in control groups (cortex:12.71 ± 3.01 vs 6.35 ± 4.13, N = 5, hippocampus: 14.25 ± 5.88 vs 8.52 ± 2.09, N = 5) (P 0.05). with 2 weeks of prior XYW administration (LPS + XYW), demonstrated significantly lower levels of Indoleamine 2,3-dioxygenase (IDO) in different regions (cortex: 12.71 ± 3.01 vs 7.71 ± 2.72, N = 5, hippocampus: 14.25 ± 5.88 vs 12.56 ± 4.73, N = 5) (P 0.05 or P 0.01) (B1-2: t-test). (C, D) Rats, LPS-induced decreased in 5-HT transcription (cortex:0.62 ± 0.15 vs 1.03 ± 0.22 (control) vs 1.10 ± 0.20 (sham), N = 6, hippocampus: 0.69 ± 0.08 vs 1.02 ± 0.26 (control) vs 1.02 ± 0.14 (sham), N = 6 vs 5 vs 5) and increase in IDO transcription in the cortex and hippocampus [cortex:2.26 ± 0.82 vs 1.21 ± 0.9 (control) vs 0.89 ± 0.42 (sham), N = 6, hippocampus: 2.60 ± 1.11 vs 1.04 ± 0.36 (control) vs 1.40 ± 0.79 (sham), N = 6 vs 5 vs 5] (P 0.05 or P 0.01), with 2 weeks of prior XYW administration (LPS + XYW), exhibited significantly higher levels of 5-hydroxytryptamine (5-HT) [cortex: 0.62 ± 0.15 vs 0.82 ± 0.14 (0.93 g/kg) vs 1.00 ± 0.45 (1.86 g/kg), N = 6, hippocampus: 0.69 ± 0.08 vs 1.07 ± 0.16 (0.93 g/kg) vs 1.00 ± 0.20 (1.86 g/kg), N = 6 vs 5 vs 6] and lower levels of Indoleamine 2,3-dioxygenase (IDO) in the cortex and hippocampus [cortex::2.26 ± 0.82 vs 0.83 ± 0.46 (0.93 g/kg) vs 1.70 ± 1.16 (1.86 g/kg), N = 6, hippocampus: 2.60 ± 1.11 vs 0.32 ± 0.14 (0.93 g/kg) vs 0.73 ± 0.35 (1.86 g/kg), N = 6 vs 5 vs 6] (P 0.05 or P 0.01) (C1-2: t-test, D1-2: Mann-Whitney test). Compared with the LPS group, *P < 0.05,**P < 0.01.

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