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LPS administration caused hippocampal neuronal damage. (A, B) Mice, LPS-treated reduced Nissl bodies, and a significant decrease in the average optical density [28.69 ± 3.40 vs 48.14 ± 5.03 (control), N = 4] (P 0.05 or P 0.01), with 2 weeks of prior XYW administration (LPS + XYW), exhibited a significant improvement of the average optical density value in Nissl bodies than the control rats (28.69 ± 3.40 vs 38.54 ± 0.78, N = 4) (P 0.01) (B: t-test).
