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Cartoon of bi-directional manipulation of rats into a PHT-responsive or resistant state by inhibiting or activating subicular pyramidal neurons (SPN). ChR2: channelrhodopsin-2; Acrh: archaerhodopsin; hM3Dq: Gq-coupled human M3 muscarinic receptor; hM4Di: Gi-coupled human M4 muscarinic receptor; CNO: clozapine-N-oxide.
