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. 2019 Aug 20;35(6):1024–1034. doi: 10.1007/s12264-019-00421-5

Fig. 2.

Fig. 2

Gedunin degrades mHTT via the proteasomal pathway. A, B Gedunin promotes the proteasome clearance of mHTT. Immunoblots of cells treated with the proteasome inhibitor MG132 (5 μmol/L and 10 μmol/L) (A), or the autophagy inhibitor bafilomycin A1 (BafA1; 0.5 μmol/L and 1 μmol/L) (B) for 16 h. C, D Fluorescence images (C) and analysis (D) of EGFP-HD-Q74-transfected Neuro-2a cells incubated with Gedunin (20 μmol/L) and MG132 (10 μmol/L) for 16 h. Data are presented as the mean ± SD of three independent experiments. P < 0.05. Scale bar, 50 µm; Magnification, × 40.