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. 2019 Aug 20;35(6):1024–1034. doi: 10.1007/s12264-019-00421-5

Fig. 3.

Fig. 3

Gedunin degrades endogenous mHTT in fibroblasts from HD patients. A Representative images of mHTT and HTT aggregates in fibroblasts from HD patients and healthy siblings after treatment with Gedunin (white arrowheads, smaller mHTT fragments; green arrowheads, intranuclear inclusions). B Change in mHTT aggregate size in the Gedunin-treated group compared with control (mean ± SD; **P < 0.001, one-way ANOVA, non-parametric and multiple comparisons). C Intranuclear inclusions of mHTT in the Gedunin-treated group compared with control (mean ± SD; **P < 0.001, non-parametric one-way ANOVA, multiple comparisons). D Changes in HTT aggregates in the Gedunin-treated group compared with control.