Skip to main content
. 2019 Aug 20;35(6):1024–1034. doi: 10.1007/s12264-019-00421-5

Fig. 6.

Fig. 6

Gedunin degrades endogenous mHTT in neurons derived from iPSCs from an HD patient. A Representative images of mHTT aggregates and intranuclear inclusions in HD neurons on days 50, 57, and 62 after treatment with a single dose of 5 µmol/L Gedunin on day 47, and untreated controls. Scale bar, 40 µm. (i, ii and iii showed the typical morphology of mHTT aggregates in Gedunin treated cells and control cells). B Size of mHTT aggregates in Gedunin-treated neurons compared with untreated neurons on days 50, 57, and 62 after treatment with a single dose of 5 µmol/L Gedunin on day 47 (mean ± SEM; two-way ANOVA, multiple comparisons). C Intranuclear inclusions of mHTT aggregates in Gedunin-treated neurons compared with untreated neurons on days 50, 57, and 62 after treatment with a single dose of 5 µmol/L Gedunin on day 47 (mean ± SD; *P < 0.05, two-way ANOVA, multiple comparisons).