Table 2.
Knocking down MAN1 in adults lengthens the period of the locomotor rhythm.
| Genotype | Period (h) ± SEM | Power ± SEM | %Rhythmic | n |
|---|---|---|---|---|
| Ethanol-treated | ||||
| Udcr2/+;pdf-GS/+ | 23.49 ± 0.03 | 152.41 ± 8.75 | 100 | 48 |
| UMAN1RNAi-1/+ | 24.14 ± 0.04 | 82.40 ± 4.53 | 98 | 49 |
| Udcr2/UMAN1RNAi-1;pdf-GS/+ | 24.16 ± 0.03*** | 133.76 ± 4.63### | 99 | 76 |
| pdf-GS/+ | 24.53 ± 0.05 | 134.92 ± 7.82 | 100 | 31 |
| UMAN1/+ | 23.56 ± 0.03 | 76.89 ± 6.23 | 96 | 45 |
| UMAN1/+;pdf-GS/+ | 23.50 ± 0.07 | 150.68 ± 11.94### | 100 | 11 |
| Drug-treated | ||||
| Udcr2/+;pdf-GS/+ | 24.93 ± 0.09 | 109.22 ± 7.52 | 98 | 49 |
| UMAN1RNAi-1/+ | 24.50 ± 0.37 | 107.24 ± 8.09 | 97 | 36 |
| Udcr2/UMAN1RNAi-1;pdf-GS/+ | 26.77 ± 0.10***### | 53.59 ± 3.65***### | 92 | 92 |
| pdf-GS/+ | 24.94 ± 0.08 | 80.53 ± 5.49 | 96 | 50 |
| UMAN1/+ | 23.74 ± 0.05 | 101.28 ± 5.79 | 98 | 52 |
| UMAN1/+;pdf-GS/+ | 24.92 ± 0.08### | 88.54 ± 5.35 | 91 | 87 |
One-way ANOVA, P < 0.001, Tukey’s multiple comparison test, ***P < 0.001 vs G4, ###P < 0.001 vs UAS. Drug-treated, flies treated with RU486 after eclosion; ethanol-treated, flies treated with ethanol instead of RU486 after eclosion. G4, GAL4; U, UAS.