Table 1.
Baseline features at unadjusted analysis.
| Feature | Acurate | Evolut | Lotus | Portico | Sapien3 | P |
|---|---|---|---|---|---|---|
| Patients | 234 | 703 | 151 | 347 | 541 | — |
| Age (years) | 83.5 ± 6.0 | 82.1 ± 6.7 | 82.0 ± 6.5 | 82.5 ± 6.5 | 83.1 ± 6.5 | 0.015 |
| Female gender | 156 (66.7%) | 391 (55.6%) | 83 (55.0%) | 223 (64.3%) | 288 (53.2%) | <0.001 |
| Body mass index (kg/m2) | 26.1 ± 4.5 | 26.1 ± 4.4 | 25.4 ± 3.9 | 26.8 ± 4.6 | 26.1 ± 4.6 | 0.045 |
| Diagnosis | <0.001 | |||||
| Aortic stenosis | 217 (92.7%) | 593 (85.4%) | 129 (85.4%) | 291 (83.9%) | 472 (87.3%) | |
| Mixed aortic valve disease | 9 (3.9%) | 76 (10.8%) | 18 (11.9%) | 15 (4.3%) | 53 (9.8%) | |
| Aortic regurgitation | 5 (2.1%) | 17 (2.4%) | 1 (0.7%) | 1 (0.3%) | 2 (0.4%) | |
| Degenerated bioprosthesis | 3 (1.3%) | 17 (2.4%) | 3 (2.0%) | 40 (11.5%) | 14 (2.6%) | |
| Risk | <0.001 | |||||
| Inoperable | 5 (2.1%) | 45 (6.4%) | 5 (3.3%) | 6 (1.7%) | 50 (9.2%) | |
| High | 195 (83.3%) | 618 (87.9%) | 141 (93.4%) | 278 (80.1%) | 433 (80.0%) | |
| Intermediate | 34 (14.5%) | 40 (5.7%) | 5 (3.3%) | 63 (18.2%) | 58 (10.7%) | |
| Logistic EuroSCORE | 12.9 ± 11.0 | 16.7 ± 11.6 | 16.3 ± 14.5 | 16.2 ± 11.6 | 16.7 ± 12.1 | <0.001 |
| EuroSCORE II | 4.1 ± 4.2 | 5.0 ± 4.9 | 5.0 ± 6.1 | 4.2 ± 3.9 | 5.5 ± 4.8 | <0.001 |
| STS score | 5.0 ± 3.8 | 5.6 ± 4.1 | 5.1 ± 4.2 | 6.3 ± 4.2 | 5.4 ± 4.2 | 0.054 |
| New York Heart Association class | <0.001 | |||||
| I | 1 (0.4%) | 6 (0.9%) | 5 (3.3%) | 9 (2.6%) | 13 (2.4%) | |
| II | 70 (30.0%) | 210 (31.8%) | 35 (23.2%) | 80 (23.1%) | 187 (34.6%) | |
| III | 159 (68.2%) | 407 (61.6%) | 104 (68.9%) | 251 (72.3%) | 323 (59.7%) | |
| IV | 3 (1.3%) | 38 (5.8%) | 7 (4.6%) | 7 (2.0%) | 18 (3.3%) | |
| Prior cardiac surgery | 21 (9.0%) | 38 (5.4%) | 13 (8.6%) | 22 (6.3%) | 40 (7.4%) | 0.276 |
| Prior aortic valvuloplasty | 12 (5.1%) | 33 (4.7%) | 13 (8.6%) | 14 (4.0%) | 52 (9.6%) | 0.001 |
| Pacemaker dependency | 25 (10.7%) | 50 (7.1%) | 13 (8.6%) | 31 (8.9%) | 39 (7.2%) | 0.407 |
| Prior stroke or transient ischemic attack | 21 (9.0%) | 38 (5.4%) | 13 (8.6%) | 22 (6.3%) | 40 (7.4%) | 0.276 |
| Estimated glomerular filtration rate (mL/min) | 65.1 ± 23.0 | 62.2 ± 23.8 | 66.5 ± 47.7 | 61.1 ± 24.8 | 62.6 ± 23.6 | 0.217 |
| Left ventricular ejection fraction (%) | 53 ± 11 | 52 ± 10 | 53 ± 12 | 54 ± 10 | 53 ± 10 | 0.424 |
| Peak aortic gradient (mm Hg) | 75.4 ± 21.3 | 76.4 ± 22.9 | 77.7 ± 23.4 | 71.4 ± 23.6 | 77.7 ± 20.9 | 0.014 |
| Mean aortic gradient (mm Hg) | 47.8 ± 13.8 | 47.3 ± 14.9 | 48.0 ± 14.8 | 48.0 ± 16.8 | 48.2 ± 13.8 | 0.896 |
| Aortic valve area (cm2) | 0.67 ± 0.23 | 0.67 ± 0.26 | 0.66 ± 0.24 | 0.69 ± 0.24 | 0.63 ± 0.18 | 0.040 |
| Aortic regurgitation | <0.001 | |||||
| None | 89 (38.0%) | 204 (29.0%) | 45 (29.8%) | 140 (40.4%) | 124 (22.9%) | |
| 1+ | 96 (41.0%) | 320 (45.5%) | 71 (47.0%) | 123 (35.5%) | 302 (55.8%) | |
| 2+ | 36 (15.4%) | 136 (19.4%) | 29 (19.2%) | 68 (19.6%) | 103 (19.0%) | |
| 3+ | 13 (5.6%) | 43 (6.1%) | 6 (4.0%) | 16 (4.6%) | 12 (2.2%) | |
| Porcelain aorta | 8 (3.4%) | 58 (8.3%) | 9 (6.0%) | 4 (1.2%) | 49 (9.1%) | <0.001 |
| Angiographically significant coronary artery disease | 62 (26.5%) | 198 (28.2%) | 34 (22.5%) | 44 (12.7%) | 140 (25.9%) | <0.001 |
| Iliofemoral tortuosity | <0.001 | |||||
| Mild | 73 (64.0%) | 121 (33.8%) | 41 (49.4%) | 100 (40.2%) | 135 (47.2%) | |
| Moderate | 39 (34.2%) | 193 (53.9%) | 40 (48.2%) | 145 (58.2%) | 127 (44.4%) | |
| Severe | 2 (1.8%) | 44 (12.3%) | 2 (2.4%) | 4 (1.6%) | 24 (8.4%) |