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. 2019 Nov 19;9:17057. doi: 10.1038/s41598-019-53565-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Each histogram shows the distribution of strength on the 5^th dimension obtained from 1000 iterations of permutation. Two vertical red lines indicate the upper and lower 2.5% of the histogram. Each green square oindicates the difference between pre and post medication on the 5^th dimension. In the top and bottom rows (showing the results from components 1 and 3, respectively), no significant reduction was found. For component #2 (middle row), we observed the significant reduction in terms of strength on the 5^th dimension after receiving LEV.