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. 2019 Nov 19;9:17067. doi: 10.1038/s41598-019-53633-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-25 responder and producer cells in aortitis in Il1rn^−/− mice. (a) Incidence and severity score of aortitis in Il1rn^−/− mice transferred with Il1rn^−/− BM cells (n = 13) or Il25^−/−Il1rn^−/− BM cells (n = 19) and in Il25^−/−Il1rn^−/− mice transferred with Il1rn^−/− BM cells (n = 14) or Il25^−/−Il1rn^−/− BM cells (n = 5). Data show the mean + SD. *p < 0.05 vs. Il1rn^−/− mice transferred with Il1rn^−/− BM cells. (b,c) Expression of IL-1β in CD11c⁺ DCs and (d,e) expression of TNF in Mac2⁺ macrophages prepared from the aortae of Il1rn^−/− mice after IL-25 stimulation. Data show the mean + SD (n = 130 fields; c and e). *p < 0.001 vs medium alone. Scale bars = 20 μm.