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. 2019 Nov 19;9:17033. doi: 10.1038/s41598-019-53370-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relative expression levels (2^−ΔΔCt) of the RNA-seq downstream genes of CBX2.2. CBX2.2 forced expression (Over Exp) positively regulated BMP15. Whereas, silencing (si) CBX2.2 (siCBX2.2) resulted in the downregulation of the same gene. Under overexpression (Over Exp) of CBX2.2, the genes TEX14 and BMP10 were significantly downregulated. Expressions of MAP3K15 and HOXA13 were comparable to the control. Silencing CBX2.2 (siCBX2.2) significantly enhanced the genes TEX14, BMP10, MAP3K15 and HOXA13. All graphs are the average of three independent experiments, error bars represent SD from the mean (SEM), and values are expressed as relative to control =1; ***P < 0.001; **P < 0.01; *P < 0.05. non-significant differences are not indicated.