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. 2019 Nov 19;9:16324. doi: 10.1038/s41598-019-51974-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Subjective vs EEG effects across time. (A) Significant inverse relationships were found between real-time intensity ratings and power in alpha and beta bands for all power measures (including the theta band for fractal power). A positive relationship was found between intensity and power at delta and theta bands in the oscillatory component. Increased signal diversity (LZs and LZs_N) correlated positively with intensity ratings also. Filled circles/dots correspond to clusters p < 0.01 and hollow circles for clusters p < 0.05, N = 12. Positive relationships are shown using black dots and negative relationships are shown using white dots/circles (B) Time frequency plot illustrating the associations between intensity ratings and spectral activity for DMT and placebo (red line marks beginning of injection), N = 12. (C) Temporal development of intensity, and EEG measures of spectral activity and spontaneous signal diversity (mean ± SEM, N = 12). (δ = delta, θ = theta, γ = gamma, α = alpha, β = beta, LZs = Lempel-Ziv complexity, LZs_N = normalized LZs).