Table 3.
Mean scores for all domains in the three European Organization for Research and Treatment of Cancer (EORTC) questionnaires that were not predefined end points
| Status | Baseline | Last cycle | 2 Weeks | 4 Weeks | 6 Weeks | 8 Weeks | 10 Weeks | 12 Weeks | 14 Weeks | 16 Weeks |
|---|---|---|---|---|---|---|---|---|---|---|
| QLQ-C30 | ||||||||||
| Functional scales | ||||||||||
| Role | 82 ± 23 | 56 ± 32 | 50 ± 32 | 26 ± 30 | 71 ± 27 | 79 ± 23 | 81 ± 22 | 81 ± 25 | 82 ± 25 | 85 ± 25 |
| Emotional | 75 ± 20 | 74 ± 24 | 72 ± 23 | 78 ± 19 | 80 ± 20 | 81 ± 17 | 81 ± 19 | 83 ± 16 | 82 ± 17 | 82 ± 19 |
| Cognitive | 91 ± 16 | 81 ± 25 | 82 ± 20 | 86 ± 19 | 91 ± 16 | 92 ± 16 | 91 ± 17 | 93 ± 14 | 93 ± 13 | 95 ± 12 |
| Social | 88 ± 18 | 70 ± 30 | 69 ± 27 | 78 ± 23 | 86 ± 20 | 88 ± 18 | 89 ± 18 | 89 ± 18 | 90 ± 19 | 91 ± 18 |
| Symptom scores | ||||||||||
| Nausea and vomiting | 12 ± 23 | 28 ± 30 | 32 ± 32 | 13 ± 20 | 10 ± 19 | 5 ± 15 | 3 ± 8 | 5 ± 11 | 5 ± 11 | 1 ± 3 |
| Pain | 14 ± 19 | 32 ± 28 | 38 ± 31 | 22 ± 26 | 14 ± 20 | 11 ± 20 | 12 ± 22 | 11 ± 21 | 12 ± 24 | 9 ± 19 |
| Dyspnea | 8 ± 16 | 20 ± 26 | 22 ± 26 | 20 ± 26 | 12 ± 21 | 11 ± 21 | 11 ± 21 | 13 ± 19 | 11 ± 19 | 8 ± 15 |
| Insomnia | 27 ± 30 | 35 ± 33 | 33 ± 34 | 24 ± 31 | 20 ± 25 | 16 ± 24 | 18 ± 24 | 17 ± 26 | 14 ± 20 | 12 ± 25 |
| Loss of appetite | 21 ± 28 | 46 ± 35 | 52 ± 35 | 33 ± 34 | 18 ± 26 | 12 ± 24 | 12 ± 22 | 12 ± 24 | 11 ± 21 | 7 ± 17 |
| Constipation | 9 ± 21 | 25 ± 33 | 25 ± 32 | 13 ± 24 | 7 ± 16 | 5 ± 14 | 7 ± 15 | 4 ± 13 | 4 ± 10 | 7 ± 17 |
| Diarrhea | 6 ± 17 | 16 ± 26 | 15 ± 26 | 5 ± 16 | 4 ± 12 | 5 ± 13 | 7 ± 13 | 3 ± 9 | 4 ± 13 | 5 ± 12 |
| Financial worries | 3 ± 12 | 8 ± 22 | 6 ± 18 | 5 ± 14 | 5 ± 17 | 5 ± 16 | 4 ± 16 | 4 ± 13 | 4 ± 10 | 4 ± 11 |
| QLQ-OG25 | ||||||||||
| Symptom scores | ||||||||||
| Dysphagia | 27 ± 25 | 41 ± 28 | 56 ± 30 | 25 ± 25 | 16 ± 19 | 13 ± 21 | 10 ± 17 | 6 ± 12 | 6 ± 15 | 4 ± 7 |
| Eating | 42 ± 28 | 57 ± 28 | 62 ± 28 | 40 ± 31 | 27 ± 28 | 20 ± 27 | 16 ± 23 | 13 ± 20 | 10 ± 17 | 9 ± 15 |
| Reflux | 9 ± 18 | 14 ± 23 | 16 ± 26 | 8 ± 21 | 5 ± 14 | 3 ± 10 | 3 ± 12 | 3 ± 11 | 1 ± 6 | 1 ± 7 |
| Pain and discomfort | 15 ± 23 | 29 ± 28 | 30 ± 32 | 22 ± 28 | 14 ± 23 | 13 ± 22 | 10 ± 1912 | 7 ± 17 | 7 ± 17 | 10 ± 20 |
| Anxiety | 52 ± 25 | 46 ± 26 | 47 ± 27 | 43 ± 25 | 41 ± 27 | 43 ± 26 | 42 ± 26 | 41 ± 22 | 39 ± 26 | 36 ± 27 |
| Eating with others | 27 ± 33 | 34 ± 35 | 36 ± 26 | 21 ± 30 | 11 ± 24 | 7 ± 17 | 5 ± 12 | 5 ± 14 | 4 ± 10 | 1 ± 7 |
| Dry mouth | 13 ± 23 | 26 ± 28 | 29 ± 30 | 17 ± 24 | 13 ± 20 | 9 ± 20 | 12 ± 21 | 13 ± 27 | 9 ± 22 | 7 ± 14 |
| Trouble with taste | 18 ± 32 | 44 ± 37 | 46 ± 35 | 32 ± 32 | 21 ± 27 | 12 ± 24 | 10 ± 20 | 8 ± 20 | 5 ± 12 | 7 ± 17 |
| Trouble swallowing saliva | 13 ± 27 | 24 ± 32 | 24 ± 30 | 14 ± 26 | 7 ± 18 | 5 ± 15 | 3 ± 11 | 3 ± 12 | 2 ± 8 | 3 ± 9 |
| Choking when swallowing | 10 ± 22 | 9 ± 17 | 9 ± 18 | 5 ± 14 | 3 ± 10 | 4 ± 13 | 2 ± 9 | 4 ± 13 | 5 ± 14 | 3 ± 9 |
| Trouble with coughing | 26 ± 26 | 32 ± 28 | 34 ± 28 | 28 ± 27 | 21 ± 23 | 23 ± 24 | 19 ± 24 | 19 ± 25 | 17 ± 22 | 16 ± 17 |
| Trouble talking | 6 ± 18 | 10 ± 19 | 13 ± 24 | 8 ± 18 | 3 ± 10 | 3 ± 11 | 5 ± 13 | 4 ± 13 | 4 ± 10 | 4 ± 11 |
| Hair loss | 10 ± 25 | 22 ± 29 | 19 ± 26 | 21 ± 29 | 19 ± 31 | 16 ± 26 | 14 ± 28 | 14 ± 31 | 17 ± 36 | 5 ± 13 |
| QLQ-CIPN20 | ||||||||||
| Autonomic scale | 11 ± 15 | 21 ± 19 | 22 ± 19 | 18 ± 18 | 14 ± 16 | 14 ± 15 | 14 ± 15 | 14 ± 16 | 14 ± 18 | 14 ± 18 |
Scores are presented as means ± standard deviations