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. 2019 Jun 13;35(6):1045–1057. doi: 10.1007/s12264-019-00400-w

Fig. 5.

Fig. 5

Genes were differentially expressed between each mutant and the wildtype. Primary mouse cortical neurons were transfected with control, SETD1A WT, R913C, Q269R, G1369R or R1392H vectors. A Heatmap showing the common differentially-expressed genes in the total transcriptome of each mutant group versus the WT group. Each column represents one gene. B–C Venn Analysis of the common differentially-expressed genes (B) and the core network (C). D RT-qPCR results of Neurl4 normalized to Gapdh (one-way ANOVA with Dunnett’s multiple comparisons test, *P < 0.5). E GO analysis of the target genes (SETD1A WT vs R1392H).