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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Virchows Arch. 2019 Jun 17;475(5):537–549. doi: 10.1007/s00428-019-02601-0

Figure 2.

Figure 2.

Major International Endocervical Adenocarcinoma Criteria and Classification (IECC) HPV-associated types: (A) Usual-type endocervical adenocarcinoma (ECA) exhibiting mucin depletion (<50% of cells) and (B) apical “floating” mitoses and apoptotic debris, (C) mucinous not otherwise specified (NOS)-type ECA exhibiting abundant intracytoplasmic mucin (≥50% of cells), (D) mucinous intestinal-type ECA (goblet cells in ≥50% of cells), (E) mucinous signet-ring type ECA (signet-ring morphology in ≥50% of tumor cells), (F) invasive stratified mucin-producing adenocarcinoma (iSMILE), (G) villoglandular-type ECA and (H) micropapillary-type ECA.