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. 2019 Nov 18;22(1):10–21. doi: 10.1016/j.neo.2019.09.001

Figure 1.

Figure 1

Histopathology, immunohistochemistry and fluorescence in situ hybridization (FISH) analysis of EGFR in primary GBM. (A) Pleomorphic, astrocytic tumor cells, (B) prominent microvascular proliferation and (C) presence of necrosis. (D) Ki-67 positive cells ratio indicated a higher proliferation range. (E) EGFR overexpression with a level 3 and (F) with a level 2 was present. (G) Tumor cells showing a high level of EGFR amplification, (H) cells with a low level of EGFR amplification and (I) cells without EGFR amplification, determined by FISH.