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. 2019 Nov 18;22(1):10–21. doi: 10.1016/j.neo.2019.09.001

Figure 3.

Figure 3

Accumulation of somatic copy number alterations (CNAs) associates to overall survival. (A) Green line represents survival in patients which tumors showed more than 4 gene gains (n = 17, mean = 278.8 days) and blue line represents survival in patients which tumors showed 4 or less gene gains (n = 25, mean = 477.6 days), reflecting a statistical association (p = 0.025*). (B) Green line represents survival in patients which tumors showed more than 10 gene losses (n = 15, mean = 193.3 days) and blue line represents survival in patients which tumors showed 10 or less gene losses (n = 27, mean = 452.7 days), reflecting an even stronger statistical association (p = 0.009**). In two cases was impossible to achieve survival data. (C) Somatic CNAs that were differentially found among the EGFR groups. CDKN2A and CDKN2B were significantly more altered in H-amp GBs compared with N-amp GBs (p = 0.030* in both cases). LARGE1, PARK2 and CDK6 were significantly more altered in both H-amp and L-amp GBMs than in N-amp GBs (p = 0.009**, p = 0.046* and p = 0.046*, respectively). Definitions: *p < 0.05 and **p < 0.01; CNAs, copy number alterations; H-amp, glioblastomas with a high number of extra copies of EGFR; L-amp, glioblastomas with a low number of additional copies of EGFR; N-amp, glioblastomas without EGFR amplification.