Table 1.
Clinical and histopathological data and genetic status of EGFR in 46 GB cases. T: temporal; F: frontal; P: parietal; O: occipital; CC: callosa commissure; RT: radiotherapy; CH: chemotherapy; amp: amplification; wt: wild type; EGFRvIII: EGFR mutant form.
| Case | Age/Sex | Location | Size (cm) | Treatment | Survival (months) | Ki-67 (%) | EGFR expression | EGFRampl. | EGFRwt/mutant | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 56/F | T | 2 | RT + CH | 23 | 5 | 3 | 2 | EGFRwt | |
| 2 | 72/F | F | 6 | RT + CH | 8 | 20 | 3 | 3 | EGFRvIII | |
| 3 | 63/F | T | 7 | RT + CH | 11 | 8,5 | 3 | 3 | EGFRvIII | |
| H-amp | 4 | 69/M | T | 6 | RT | 7 | 15 | 3 | 2 | EGFRvIII |
| 5 | 48/M | T | 5,3 | RT + CH | 11 | 3 | 3 | 2 | EGFRwt | |
| 6 | 55/F | CC | 4 | CH | 4 | 14,5 | 3 | 3 | EGFRvIII | |
| 7 | 59/F | P | 2,6 | RT | 18 | 40 | 3 | 3 | EGFRvIII | |
| 8 | 58/F | T | 6 | RT + CH | 23 | 35 | 3 | 2 | EGFRvIII | |
| 9 | 61/M | T | 8 | RT + CH | 12 | 4 | 3 | 3 | EGFRwt | |
| 10 | 59/F | P | 2 | RT + CH | 20 | 30 | 3 | 3 | EGFRwt | |
| 11 | 66/M | P | 4 | RT + CH | 6 | 19,7 | 2 | 3 | EGFRwt | |
| L-amp | 12 | 55/M | T | 3 | RT + CH | 5 | 6 | 2 | 2 | EGFRwt |
| 13 | 66/F | F | 4 | RT | 36 | 8 | 2 | 2 | EGFRwt | |
| 14 | 69/M | T | 6 | RT + CH | 12 | 50 | 2 | 3 | EGFRvIII | |
| 15 | 66/M | F | 2 | RT | 5 | 45 | 3 | 3 | EGFRvIII | |
| 16 | 61/F | F | 6 | RT | 2 | 22,5 | 3 | 3 | EGFRvIII | |
| 17 | 58/F | O | 2 | RT + CH | 20 | 5 | 2 | 2 | EGFRwt | |
| 18 | 57/M | F | 3,5 | RT | 17 | 12 | 2 | 3 | EGFRwt | |
| 19 | 71/M | F | 2 | RT + CH | 3 | 20 | 2 | 3 | EGFRwt | |
| 20 | 63/M | T | 2 | RT | 5 | 43 | 2 | 2 | EGFRwt | |
| 21 | 45/M | T | 7 | RT | - | 3 | 1 | 1 | EGFRwt | |
| 22 | 24/M | T | 4 | RT | 2 | 30 | 1 | 1 | EGFRwt | |
| 23 | 67/M | T | 5 | RT + CH | 7 | 43 | 0 | 1 | EGFRwt | |
| 24 | 73/M | P | 2,5 | RT | 5 | 22 | 0 | 1 | EGFRwt | |
| 25 | 45/M | P | 2,5 | RT + CH | 10 | 6,8 | 2 | 1 | EGFRwt | |
| 26 | 42/M | P | 2 | RT | - | 3 | 0 | 1 | EGFRwt | |
| 27 | 60/M | P | 3,7 | RT | 5 | 2 | 1 | 1 | EGFRwt | |
| 28 | 31/F | F | 2 | RT | - | 3 | 1 | 1 | EGFRwt | |
| N-amp | 29 | 73/F | P | 6 | RT + CH | 26 | 1 | 1 | 1 | EGFRwt |
| 30 | 35/M | T | 2 | RT | 38 | 30 | 1 | 1 | EGFRwt | |
| 31 | 74/F | F | 4 | NONE | 1 | 12 | 0 | 0 | EGFRwt | |
| 32 | 66/M | T | 4 | RT + CH | 11 | 5 | 0 | 0 | EGFRwt | |
| 33 | 35/F | P | 1 | RT | - | 2 | 0 | 0 | EGFRwt | |
| 34 | 54/M | T | 4 | RT + CH | 5 | 26 | 0 | 0 | EGFRwt | |
| 35 | 63/M | F | 4 | RT + CH | 36 | 23 | 0 | 0 | EGFRwt | |
| 36 | 75/M | P | 3,5 | NONE | 6 | 44 | 2 | 0 | EGFRwt | |
| 37 | 55/M | F | 2 | RT + CH | 26 | 3 | 1 | 0 | EGFRwt | |
| 38 | 73/M | O | 6,6 | RT + CH | 11 | 2 | 0 | 0 | EGFRwt | |
| 39 | 63/F | P | 4 | CH | 9 | 2 | 1 | 0 | EGFRwt | |
| 40 | 67/M | P | 3 | RT + CH | 21 | 7,5 | 2 | 0 | EGFRwt | |
| 41 | 75/F | F | 1 | NONE | 2 | 2 | 0 | 0 | EGFRwt | |
| 42 | 60/M | F | 6 | RT + CH | 2 | 1 | 0 | 0 | EGFRwt | |
| 43 | 50/M | T | 3,5 | RT | 10 | 5 | 0 | 0 | EGFRwt | |
| 44 | 65/F | T | 1 | RT + CH | 22 | 1 | 2 | 0 | EGFRwt | |
| 45 | 38/M | P | 1 | RT | 30 | 1 | 0 | 0 | EGFRwt | |
| 46 | 52/M | T | 2 | RT | 23 | 2 | 0 | 0 | EGFRwt |