Figure 3.
Progressive Lymphatic Dysfunction Is Associated with Disease
Age, environmental, and infection-related progressive lymphatic dysfunction may in part underscore pathophysiology associated with cancer, neurodegeneration, and other disease states. Changes in lymphatic transport affect peripheral tissue fluid dynamics, cell migration patterns, and solute clearance and lymph node (LN) fibrosis that drive tissue accumulation of inflammatory mediators and disrupt spatiotemporal control over protective immune responses.