Figure 3.

Transition Paths among Different Cell States

(A) Fixed points and kinetic transition paths between different cell states. Solid magenta lines represent transition paths between nearby states (from E to A, A to M, and M to Met state) in metastatic progression direction. Solid cyan lines represent transition paths between nearby states (from Met to M, M to A, and A to E state) in de-metastasis direction. The dashed lines represent the direct transition path from E to Met state and from Met to E state, respectively.

(B and C) Discrete transition paths from E state to Met state (B) and from Met state to E state (C) in terms of expression levels of 16 genes and metabolites. Relative gene expression levels are discretized to 0 or 1; 1 represents that the corresponding genes are in the activated state and 0 represents that the corresponding genes are in the repressed state. X axis shows the time points along the transition path. E, epithelial state; A, abnormal metabolic state; M, mesenchymal state; Met, metastasis state.

See also Table S4.