Figure 5.

Global Sensitivity Analysis for Parameters Based on the Transition Action for the Metabolism-EMT-Metastasis Model

Y axis represents the 25 parameters. X axis represents the percentage of the change of the transition action ($\mathcal{S}$) relative to $\mathcal{S}$ with default parameters. Here, $S_{E\to M}$ represents the transition action from attractor E to attractor M (magenta bars) and $S_{M\to E}$ represents the transition action from attractor M to attractor E (cyan bars). The top 25 parameters are picked, in which the first 15 parameters represent the regulatory strength (λ) and the last 10 parameters represent the synthesis rate (g) for 10 proteins or metabolites. See Supplemental Information for the complete sensitivity analysis of 61 parameters.

(A) Each parameter is increased by 10%, individually.

(B) Each parameter is decreased by 10%, individually.