Table 1.

Major Model Predictions and Experimental Supports

Model Predictions	Supporting References
In metastatic progression, there exists an abnormal metabolic state.	Prediction
Forward and reverse paths for EMT and metastasis are not identical.	(Zhang et al., 2014)
Metastasis is a stepwise progress, i.e., abnormal metabolism, EMT, and metastasis should be activated in a cascade.	Prediction
ROS changes the levels in the very early stage of the cell fate decision process toward EMT or metastasis.	Prediction
Over-expression of P53 attenuates EMT and metastasis progression.	(Powell et al., 2014)
Over-expression of ZEB promotes EMT.	(Sánchez-Tilló et al., 2011, Korpal et al., 2008)
Over-expression of miR-145 attenuates EMT.	(Wang et al., 2017)
Over-expression of HIF-1 promotes EMT and metastasis.	(Liao et al., 2007)
Inhibition of ROS promotes EMT and metastasis.	(Piskounova et al., 2015, Gill et al., 2016)
Inhibition of AMPK promotes EMT and metastasis.	(Chen et al., 2017)