5.4. Analysis.

Comparison 5 Antimicrobial treatment (CHX or iodine‐NaF and prophylaxis) versus placebo, Outcome 4 Adverse events for mother or child.

Adverse events for mother or child
Study
Dasanayake 1993	Quote: "Eight mothers in the treatment group and three in the control group reported adverse effects from the topical application of treatment solutions, but the difference was not statistically significant (P = 0.09)."
Dasanayake 2002	Quote: "Twenty adverse events were recorded for 14 women (9 in the treatment group and 5 in the control group): staining of teeth (8); minor ulcers (4); nausea (1), and gingival irritation or burning sensation during application (7). None of these events were classified as serious by FDA criteria, and all subjects have recovered uneventfully. There were more events in the treatment group (n = 13) compared to the control group (n = 7), but the difference was not statistically significant (p = 0.13), nor was the difference in the number of women experiencing adverse events (p = 0.25)."