| 2.1 Preterm birth less than 34 weeks |
5 |
1503 |
Risk Ratio (M‐H, Random, 95% CI) |
0.90 [0.66, 1.23] |
| 2.2 Preterm birth less than 34 weeks subgroup by dose |
5 |
1503 |
Risk Ratio (M‐H, Random, 95% CI) |
0.91 [0.69, 1.21] |
| 2.2.1 Low dose (200 mg or less daily) |
4 |
1267 |
Risk Ratio (M‐H, Random, 95% CI) |
0.93 [0.63, 1.37] |
| 2.2.2 High dose (more than 200 mg daily) |
2 |
236 |
Risk Ratio (M‐H, Random, 95% CI) |
0.74 [0.40, 1.39] |
| 2.3 Preterm birth less than 34 weeks subgroup by timing |
5 |
1503 |
Risk Ratio (M‐H, Random, 95% CI) |
0.90 [0.66, 1.23] |
| 2.3.1 Starting before 20 weeks' gestation |
1 |
91 |
Risk Ratio (M‐H, Random, 95% CI) |
0.69 [0.30, 1.58] |
| 2.3.2 Starting after 20 weeks' gestation |
3 |
1032 |
Risk Ratio (M‐H, Random, 95% CI) |
0.80 [0.60, 1.07] |
| 2.3.3 Mixed timing of start |
1 |
380 |
Risk Ratio (M‐H, Random, 95% CI) |
1.35 [0.90, 2.02] |
| 2.4 Perinatal death |
3 |
2287 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.23 [0.74, 2.06] |
| 2.5 Perinatal death subgroup by dose |
3 |
2287 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.23 [0.74, 2.06] |
| 2.5.1 Low dose (200 mg or less daily) |
3 |
2287 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.23 [0.74, 2.06] |
| 2.6 Perinatal death subgroup by timing |
3 |
2287 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.23 [0.74, 2.06] |
| 2.6.1 Starting before 20 weeks' gestation |
1 |
171 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.98 [0.18, 21.39] |
| 2.6.2 Starting after 20 weeks' gestation |
1 |
1346 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.11 [0.51, 2.42] |
| 2.6.3 Mixed timing of start |
1 |
770 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.29 [0.63, 2.61] |
| 2.7 Prelabour rupture of the membranes |
1 |
290 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.82 [0.20, 3.38] |
| 2.8 Preterm birth less than 37 weeks |
6 |
1597 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.97 [0.89, 1.06] |
| 2.9 Preterm birth less than 28 weeks |
3 |
1345 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.53 [0.79, 2.97] |
| 2.10 Adverse drug reaction |
2 |
562 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.99 [0.90, 1.09] |
| 2.11 Caesarean section |
5 |
1919 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.92 [0.86, 0.98] |
| 2.12 Satisfaction with therapy |
1 |
494 |
Mean Difference (IV, Fixed, 95% CI) |
0.00 [‐0.35, 0.35] |
| 2.13 Antenatal tocolysis |
4 |
1420 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.80 [0.62, 1.02] |
| 2.14 Antenatal corticosteroids |
4 |
1422 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.87 [0.71, 1.06] |
| 2.15 Infant birthweight less than 2500 g |
3 |
2640 |
Risk Ratio (M‐H, Random, 95% CI) |
0.95 [0.84, 1.07] |
| 2.16 Apgar score < 7 at 5 minutes |
3 |
2410 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.65 [0.35, 1.19] |
| 2.17 Respiratory distress syndrome |
3 |
2121 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.98 [0.78, 1.22] |
| 2.18 Use of mechanical ventilation |
4 |
2695 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.70 [0.52, 0.94] |
| 2.19 Intraventricular haemorrhage ‐ all grades |
1 |
1333 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.70 [0.62, 4.66] |
| 2.20 Retinopathy of prematurity |
2 |
1945 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.07 [0.45, 2.54] |
| 2.21 Necrotising enterocolitis |
3 |
2117 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.52 [0.13, 2.06] |
| 2.22 Neonatal sepsis |
2 |
1944 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.41 [0.86, 2.33] |
| 2.23 Fetal death |
3 |
2328 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.38 [0.65, 2.90] |
| 2.24 Neonatal death |
3 |
2905 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.53 [0.75, 3.15] |
| 2.25 Admission to NICU |
4 |
3613 |
Risk Ratio (M‐H, Random, 95% CI) |
0.95 [0.83, 1.08] |
| 2.26 Patent ductus arteriosus |
2 |
1946 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.76 [0.47, 1.22] |
| 2.27 Sensitivity analysis for perinatal death (assuming total non‐independence) |
3 |
1144 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.22 [0.61, 2.44] |
| 2.28 Sensitivity analysis for perinatal death (assuming 1% non‐independence) |
3 |
2263 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.23 [0.74, 2.06] |
