Skip to main content
. Author manuscript; available in PMC: 2019 Nov 20.
Published in final edited form as: Cell Stem Cell. 2008 Sep 11;3(3):279–288. doi: 10.1016/j.stem.2008.07.025

Figure 2. Stem Cell Astrocytes and Transit-Amplifying Cells Lie Adjacent to Blood Vessels in the SVZ.

Figure 2

(A) A small fraction of dividing cells near blood vessels are astrocytes. Arrowhead points to Ki67+ (blue), GFP-expressing astrocyte (green) in GFAP::GFP mice. Scale bar, 20 μm.

(B) Many LRCs (green) are found adjacent to blood vessels (arrowheads). Scale bar, 50 μm.

(C) GFP+ LRCs (38% of all LRCs, arrowhead) are frequently found near blood vessels. Scale bar, 20 μm.

(D and E) The majority of dividing cells that lie adjacent to the SVZ vascular plexus are transit-amplifying C cells. (D) Most EGFR+ cells (green) express the C cell marker Mash1 (blue). (E) Z stack projection of whole-mount SVZ showing that the vast majority of Ki67 immunoreactive cells (blue) near blood vessels are EGFR+ (green). Often, these cells were found in clusters (arrow) near the vasculature. Scale bars, 50 μm.