Table 1.
Effects of genistein on menopause symptoms and some related diseases.
| Symptoms/Disease | Genistein Effects |
|---|---|
| Vasomotor | Reduction of hot flashes, night sweats, and sleep disturbances frequency; as well as depression symptoms and memory loss |
| Cardiovascular | Reduction of myocardial necrosis, macrophage and serum levels of TNF-α, severity of atherosclerosis, and myocardial infarctions incidence |
| Obesity | Reduction of serum concentration of total cholesterol, LDL, triglycerides, and HDL |
| Diabetes | Reduction of fasting glucose concentration, insulin resistance, and improves glycemic metabolism |
| Cancer | Reduces the incidence of breast, hepatocellular, lung, gastric, and ovarian cancer |
| Stress responses | Improves 5-HT metabolism, stabilizes MAO activity, and improves turnover ratio of 5-HIAA/5-HT |