Table 5.
Calculated physicochemical and pharmacokinetic parameters.
| Compounds | logP | MW | Lipinski | Lead-like | Caco-2 | CNS |
|---|---|---|---|---|---|---|
| M29 | 1.94 | 275.3 | 0 violations | 0 violations | Highly permeable | Penetrant |
| M31 | 2.21 | 289.33 | 0 violations | 0 violations | Highly permeable | Penetrant |
| M32 | 2.98 | 309.74 | 0 violations | 0 violations | Highly permeable | Penetrant |
| M43 (7a) | 3.79 | 336.37 | 0 violations | 0 violations | Highly permeable | Penetrant |
| FR1 | 3.3 | 284.31 | 0 violations | 0 violations | Highly permeable | Penetrant |
| FR2 | 2.32 | 301.34 | 0 violations | 0 violations | Highly permeable | Penetrant |
| FR3 | 4.33 | 328.36 | 0 violations | 1 violation | Highly permeable | Penetrant |
| FR4 | 4.57 | 354.78 | 0 violations | 1 violation | Highly permeable | Penetrant |
| FR5 | 3.77 | 296.32 | 0 violations | 0 violations | Highly permeable | Penetrant |
| SP1 | 3.97 | 350.39 | 0 violations | 0 violations | Highly permeable | Penetrant |
| 5d | 4.72 | 376.43 | 0 violations | 1 violation | Highly permeable | Penetrant |
| 7b | 4.49 | 364.42 | 0 violations | 1 violation | Highly permeable | Penetrant |
| 7k | 4.79 | 378.45 | 0 violations | 1 violation | Highly permeable | Penetrant |
| 7c | 4.99 | 384.84 | 0 violations | 1 violation | Highly permeable | Weak Penetrant |