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Schematic representation of biased signaling at CB1. Structurally different ligands will induce diverse conformations of the receptor, which may then favor one of the possible signaling pathways over others. In this diagram, the unbiased agonist CP55,940 engages the CB1 and activates both G protein- and β-arrestin-dependent signaling pathways. PNR-4-20 is biased toward the activation of the Gαi heterotrimer over β-arrestin, while ORG27569 favorably activates β-arrestin.
