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. 2019 Oct 28;24(21):3886. doi: 10.3390/molecules24213886

Table 1.

Selected data of reported antigiardial agents.

Compound Activity Ref.
graphic file with name molecules-24-03886-i001.jpg G. lamblia
[IC50 (µg/mL)]
[61]
7 4.62 ± 0.12
MTZ 0.86 ± 0.03
graphic file with name molecules-24-03886-i002.jpg G. lamblia
[IC50 (µg/mL)]
[62]
8 84.2
MTZ 1.22
graphic file with name molecules-24-03886-i003.jpg G. intestinalis
[IC50 (µM)]
[63]
9a 0.122
9b 0.151
Aminitrozole 0.490
MTZ 5.360
graphic file with name molecules-24-03886-i004.jpg G. lamblia
[IC50 (µM)]
[64]
10 19.58
MTZ 62.48
graphic file with name molecules-24-03886-i005.jpg G. lamblia
[IC50 (µg/mL)]
[65]
11 30.6
MTZ 0.21
graphic file with name molecules-24-03886-i006.jpg G. intestinalis
[IC50 (µM)]
[66]
12a 0.027 ± 0.002
12b 0.022 ± 0.001
12c 0.027 ± 0.002
12d 0.021 ± 0.005
Nitazoxamide 0.015 ± 0.002
Mebendazole 0.046 ± 0.009
MTZ 1.224 ± 0.021
graphic file with name molecules-24-03886-i007.jpg G. duodenalis
[IC50 (µg/mL)]
[67]
13a 14.3
13b 8.2
MTZ 11.4
graphic file with name molecules-24-03886-i008.jpg G. intestinalis
[IC50 (µM)]
[68]
14a 0.87
14b 0.39
MTZ 1.40
graphic file with name molecules-24-03886-i009.jpg G. lamblia
[IC50 (µM)]
[69]
Disulfiram (15) 6.6