Table 1.

$\alpha$-CA-II single SNVs rs IDs, associated residue-variant substitutions, model z-DOPE score, MAF and predicted variant consequences. Global MAF obtained from gnomAD.

rs ID	Variation	z-DOPE Score	MAF	VAPOR Analysis
				I-Mutant		MUpro
				$\mathcal{\Delta }\mathcal{\Delta }$G	Stability	$\mathcal{\Delta }\mathcal{\Delta }$G	Stability
rs118203931	K18E	−2.204	<0.01	−1.30	Decrease	−0.499	Decrease
	K18Q	−2.203	<0.01	−1.24	Decrease	−0.655	Decrease
rs118203933	H107Y	−2.204	<0.01	0.26	Increase	−0.867	Decrease
rs118203932	P236H	−2.159	<0.01	−1.46	Decrease	−0.586	Decrease
	P236R	−2.186	<0.01	−0.60	Decrease	−0.311	Decrease
rs2228063	N252D	−2.197	0.007	0.06	Increase	−0.474	Decrease