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. 2019 Nov 2;24(21):3971. doi: 10.3390/molecules24213971

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The pharmacological activity of carbamazepine solid lipid nanoparticles; (A) the effect of free carbamazepine and carbamazepine solid lipid nanoparticles (F8) on the time to death after the administration of a lethal dose of pentylenetetrazole (PTZ), and (B) the effect of free carbamazepine and carbamazepine solid lipid nanoparticles (F8) on mean seizure scores in pentylenetetrazole (PTZ)-kindled mice. Data are presented as mean ± SD (n = 6) and were analyzed using an ANOVA followed by Bonferroni’s post hoc test at p < 0.05. * Compared to the PTZ group, # compared to the CBZ group.