Heatmap detailing the incidence of the genomic alterations included in the primary resistance in RAS and BRAF wild-type metastatic colorectal cancer patients treated with anti-EGFR monoclonal antibodies (PRESSING) panel study population. Green indicates amplifications, violet, gene fusions, and red, mutations. Blue indicates patients with high microsatellite instability (MSI) status; gray indicates patients with right-sided tumors. (*) Targeted screening for ALK, ROS1, NTRKs, RET fusions; (†) mutant allele fraction < 5%.