FIG 1.
(A) Best change from baseline in target lesion by best overall response per investigator. (B) Best reduction from baseline in maximum standardized uptake value (SUVmax) by best overall response per blinded independent central review. Target lesion was measured by sum of the product of the diameters, on the basis of computed tomography scan. SUVmax was measured by [18F]fluorodeoxyglucose–positron emission tomography. Horizontal reference line in (A) indicates the 50% reduction consistent with a response per Lugano Classification 2014. Horizontal reference line in (B) indicates the 25% reduction in SUVmax consistent with a response per Lugano positron emission tomography staging criteria.30 (*) Five patients were nonevaluable: two died before any postbaseline tumor measurements were obtained, one had inconsistent tumor codes at screening and week 6, and two had measurements after progression per investigator. (†) Five patients were nonevaluable: two had no baseline SUVmax measurements, and three had no postbaseline SUVmax measurements.