Oguzhanoglu 1999.

Methods	Single‐centre, open‐label randomised, parallel study: fluoxetine vs amitriptyline No control for symptomatic/analgesic medications use
Participants	Country: Turkey Overall: N = 52; Sex: 6 male, 41 female (sex not reported for dropouts). Chronic tension‐type headache and episodic tension‐type headache groups: N = 35; Sex: 3 male, 29 female (sex not reported for dropouts); mean age: 38.5 chronic tension‐type headache, 31.5 episodic tension‐type headache Diagnosis: migraine (n = 17), chronic tension‐type headache (n = 14) and episodic tension‐type headache (n = 21), all defined according to International Headache Society Criteria (IHS 1988) Exclusion criteria: antidepressant use in the previous year, score > 17 Hamilton Depression Scale Recruitment: from November 1996 to September 1997, no other information
Interventions	N = 22 amitriptyline to a maximum of 50 mg/day N = 25 fluoxetine 20 mg/day Duration of active treatment: unclear
Outcomes	1. Headache frequency (number of days with headache/30 days) 2. Pain intensity (not defined) 3. Headache duration (not defined)
Notes	Overall, 5 dropouts (10%) for side effects, three in the chronic tension‐type headache and episodic tension‐type headache groups Per protocol analysis. No sample size calculation
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information
Allocation concealment (selection bias)	Unclear risk	No information
Blinding (performance bias and detection bias) All outcomes	High risk	Open‐label
Incomplete outcome data (attrition bias) All outcomes	Low risk	Low dropout rate (3/35, 8.6%), reasons reported
Selective reporting (reporting bias)	Unclear risk	No information
Other bias	Unclear risk	Financial support not reported