Table 2.
Nucleotide position | Codon | Wild-type | Mutant | Amino acid substitution | Frequency (%) | |
---|---|---|---|---|---|---|
Eastern Myanmar (n = 85) |
Western Myanmar (n = 82) |
|||||
778 | 260 | AAA | GAA | K - E | 0 | 1.22 |
924 | 308 | AGG | AGT | R - S | 10.59 | 2.44 |
997 | 333 | CTT | TTT | L - F | 50.59 | 50.00 |
1111 | 371 | AAA | GAA | K - E | 20.00 | 2.44 |
1123 | 375 | AAT | GAT | N - D | 44.71 | 21.95 |
1134 | 378 | CGC | CGT | R - R | 42.35 | 19.51 |
1151 | 384 | GAT | GGT | D - G | 100.00 | 92.68 |
1153 | 385 | GAA | AAA | E - K | 50.59 | 35.37 |
1158 | 386 | AAG | AAT | K - N | 50.59 | 26.83 |
1169 | 390 | CGT | CAT | R - H | 80.00 | 92.68 |
1251 | 417 | AAT | AAA | N - K | 63.53 | 87.80 |
1257 | 419 | ATA | ATG | I - M | 12.94 | 0 |
1270 | 424 | TTA | ATA | L - I | 77.65 | 85.37 |
1309 | 437 | TGG | CGG | W - R | 62.35 | 2.44 |
1392 | 464 | ATC | ATA | I - I | 11.76 | 0 |
1425 | 475 | CCA | CCC | P - P | 1.18 | 0 |
1456 | 486 | CAA | GAA | Q - E | 0 | 2.44 |
1508 | 503 | ATA | AAA | I - K | 47.06 | 48.78 |
1538 | 513 | ACG | AAG | T - K | 3.53 | 0 |
1669 | 557 | GCT | ACT | A - T | 1.18 | 0 |
1671 | 557 | GCT | GCC | A - A | 1.18 | 0 |
1679 | 560 | AAT | ATT | N - I | 1.18 | 0 |
1703 | 568 | GTC | GGG | V - G | 1.18 | 0 |
Notes: Number of the amino acid residues is according to Sal I sequence. Text highlighted in bold indicates non-synonymous mutations