Skip to main content
. Author manuscript; available in PMC: 2019 Nov 20.
Published in final edited form as: Clin Cancer Res. 2018 May 24;24(16):3820–3828. doi: 10.1158/1078-0432.CCR-17-3348

Figure 2.

Figure 2.

AZD1775 plasma and tumor pharmacokinetics in patients with glioblastoma receiving a single oral dose. A, AZD1775 total plasma concentration-time profiles. Symbols represent observed concentrations; solid, dash, and dot lines represent pharmacokinetic profiles fitted by the final population pharmacokinetic model. B, Unbound AZD1775 tumor concentrations. C, AZD1775 total tumor-to-plasma concentration ratios. D, AZD1775 unbound tumor-to-plasma concentration ratios. Symbols represent observed data; boxplot represents 25th, 50th (median), and 75th percentiles of the observed data.