Table 2.
Population pharmacokinetic parameters for total AZD1775, estimated from the base and final covariate models, data are expressed as estimates (%RSE)
| Parameter | Base model | Covariate model |
|---|---|---|
| OFV | −36.58 | −42.63 |
| Ka (h−1) | 2.00 (114) | 2.10 (111) |
| V/F (L) | 1,500 (16) | 1,500 (17) |
| CL/F (L/hour) | 160 (15) | 160a (14) |
| Ba | 1.7 (44) | |
| IIV of Ka (CV%) | 100 (310) | 100 (300) |
| IIV of V/F (CV%) | 28 (70) | 26 (91) |
| IIV of CL/F (CV%) | 48 (23) | 40 (36) |
Abbreviations: CL/F, apparent oral clearance; IIV, interindividual variability; Ka, first-order absorption rate constant; OFV, objective function value; RSE, relative standard error of estimation; V/F, apparent volume of distribution.
a
CL/F = A + B × (GFR - 98), where A is the CL/F for a typical patient with glomerular filtration rate (GFR) of 98 mL/minute, and B represents the covariate effect of glomerular filtration rate.