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. 2019 Nov 20;16:230. doi: 10.1186/s12974-019-1627-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Protective effects of elamipretide (SS-31) on mitochondrial dysfunction induced by LPS in the mouse hippocampus. a Representative fluorescence intensity images of J-aggregates (Cy3) and JC-1 monomers (FITC) from hippocampal mitochondria in each group. The MMP level b and ATP production c in the hippocampus were measured immediately after samples were prepared from each group. Scale bars: 20 μm, Data are expressed as the mean ± SE (n = 6). **P < 0.01, ***P < 0.001 vs. CON group. #P < 0.05 vs. LPS group. SS-31 elamipretide, aCSF artificial cerebrospinal fluid, LPS lipopolysaccharide, SE standard error