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. 2019 Nov 20;7:185. doi: 10.1186/s40478-019-0826-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Kaplan-Meier analyses of unsupervised clusters. a For patients in clusters A (n = 26) and C (n = 5) median survival was 467 days and 135 days, respectively. For cluster B (n = 38) the follow-up period was too short to determine median survival. Survival of patients in cluster B was significantly better than of clusters A and C (both p < 0.0001). Survival in cluster A was significantly better than C (P = 0.008). b Oligodendroglioma patients in cluster B (diagnosed according to WHO 2016 classification, and treated with PCV) performed better than astrocytoma patients in this cluster (all treated with TMZ) (p = 0.04). Two patients (N16–06 and N16–10) were excluded from analysis because no survival data was present