Fig. 3.

Actionable gene expression in grade II/III astrocytomas, oligodendrogliomas and glioblastoma. a EGFR^vIII was detected at significant levels in 30% of glioblastomas (GB, red) but not in grade II/III astrocytomas (A) and oligodendrogliomas (O) (note the log scale of the Y-axis, expression < 5 FPM was considered EGFR^vIII-negative). b Wild-type EGFR expression is inversely correlated with expression of MET in glioblastoma (Spearman R = − 0.59; p < 0.0001). c Mean expression of ErbB3, ErbB4, and NTRK2 in GB (red) and grade II/III O/A (blue). Error bars represent the standard deviation