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. 2019 Nov 20;7:185. doi: 10.1186/s40478-019-0826-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Actionable markers in brain tumours. a overview of expression of potentially actionable targets in a subset of patients, expressed as fold change compared to the mean of the entire group. For clarity only tyrosine kinases are shown for a small selection of patients. b comparative analysis of a primary pleomorphous xantoastrocytoma and its recurrence 4 years later. c shows a selection of actionable targets in sample 13–05, a metastasis of a lung cancer. Note high expression levels of the macrophage receptor RON, MET and CTLA-4. Also VEGF isoforms 121 and 189 are detected