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Major role of PKM2 in gemcitabine resistance. The lincROR/miR-124/PTBP1/PKM2 complex is involved in the regulation of gemcitabine resistance. FASN regulates PKM2 expression and is associated with gemcitabine resistance. LincROR, long intergenic non-protein coding RNA, regulator of reprogramming PKM2, pyruvate kinase isoenzyme M2; PTBP1, polypyrimidine tract binding protein; FASN, Fatty acid synthase; miR, micro RNA.
