Table II.
Results from pathway enrichment analysis.
| Pathways | Source | P-value | Genes in the pathway |
|---|---|---|---|
| Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins | BIOCARTA | 1.19×10−08 | COL3A1, CRISPLD2, FBLN5, SPARC, MXRA5, DCN, EGFL6, TIMP3, PLXNC1, PRELP, SERPINE1, XCL2, CST3, SERPING1, CCL2, PLAT, CTGF, LUM, CTSB, XCL1, PLOD2, CXCL12 |
| Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans | BIOCARTA | 1.73×10−05 | COL3A1, CRISPLD2, FBLN5, SPARC, MXRA5, DCN, PRELP, CTGF, LUM |
| Complement and coagulation cascades | KEGG | 6.90×10−05 | SERPINE1, SERPING1, PLAT, C4A, C4B |
| Pertussis toxin-insensitive CCR5 signaling in Macrophage | BIOCARTA | 1.20×10−04 | FOS, CCL2, CXCL12 |
| Rheumatoid arthritis | KEGG | 1.29×10−04 | ATP6V1B1, HLA-DPA1, FOS, CCL2, CXCL12 |
| Ensemble of genes encoding ECM-associated proteins including ECM-affiliated proteins, ECM regulators and secreted factors | BIOCARTA | 1.85×10−04 | EGFL6, TIMP3, PLXNC1, SERPINE1, XCL2, CST3, SERPING1, CCL2, PLAT, CTSB, XCL1, PLOD2, CXCL12 |
| Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix | BIOCARTA | 3.07×10−04 | TIMP3, SERPINE1, CST3, SERPING1, PLAT, CTSB, PLOD2 |
| MAPK signaling pathway | KEGG | 4.66×10−04 | FOS, DUSP1, DUSP6, JUND, FGFR3, HSPA1A, HSPA1B |
| Pertussis | KEGG | 7.77×10−04 | FOS, SERPING1, C4A, C4B |
| Antigen processing and presentation | KEGG | 8.16×10−04 | HLA-DPA1, CTSB, HSPA1A, HSPA1B |
| Genes encoding proteoglycans | BIOCARTA | 9.00×10−04 | DCN, PRELP, LUM |
| IL-17 signaling pathway | KEGG | 1.65×10−03 | FOS, FOSB, JUND, CCL2 |
| Lectin Induced Complement Pathway | BIOCARTA | 1.87×10−03 | C4A, C4B |
| Fibrinolysis Pathway | BIOCARTA | 1.87×10−03 | SERPINE1, PLAT |
| Ether lipid metabolism | KEGG | 1.88×10−03 | PLA2G7, PLA2G16, CHPT1 |
| Estrogen signaling pathway | KEGG | 2.00×10−03 | FOS, HSPA1A, HSPA1B, GABBR1 |
| AGE-RAGE signaling pathway in diabetic complications | KEGG | 2.08×10−03 | COL3A1, EGR1, SERPINE1, CCL2 |
| Classical Complement Pathway | BIOCARTA | 2.56×10−03 | C4A, C4B |
| Platelet Amyloid Precursor Protein Pathway | BIOCARTA | 2.56×10−03 | SERPINE1, PLAT |
| B Cell Survival Pathway | BIOCARTA | 3.36×10−03 | FOS, JUND |
| Staphylococcus aureus infection | KEGG | 3.51×10−03 | HLA-DPA1, C4A, C4B |
| Genes encoding structural ECM glycoproteins | BIOCARTA | 4.29×10−03 | CRISPLD2, FBLN5, SPARC, MXRA5, CTGF |
| Complement Pathway | BIOCARTA | 4.73×10−03 | C4A, C4B |
| Osteoclast differentiation | KEGG | 5.52×10−03 | FOS, FOSB, JUNB, JUND |