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. 2019 Oct 2;18(6):5897–5904. doi: 10.3892/ol.2019.10952

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Copyright: © Fu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Induction of CTL response in tumor-bearing mice via immunization with unpulsed DCs, Pro-DCs or RNA-DCs. (A) CTL-stimulated lysis of CCSCs by pulsed or unpulsed DCs at E/T ratios of 10:1, 20:1 and 40:1. (B) Levels of IFN-γ secreted by CTLs derived from pulsed or unpulsed DCs against CCSCs at an E/T ratio of 20:1. The results represent three independent experiments. Data are presented as the mean ± standard deviation. *P<0.05 vs. PBS; ^#P<0.05 vs. unpulsed DCs; ^†P<0.05 vs. RNA-DCs. CTL, cytotoxic T lymphocyte; DC, dendritic cell; Pro-DC, tumor lysate protein-pulsed dendritic cell; RNA-DC, tumor total RNA-pulsed dendritic cell; CCSCs, colon cancer stem cells; E/T, effector-to-target; IFN-γ, interferon-γ.