Table 2. Metrics for intra- and inter-rater agreement using manual and guided segmentation. All values are presented as the median and interquartile range.

	Intra-rater
	Manual	Guided	P-value
Dice Coefficient	0.96 (0.94–0.97)	0.98 (0.97–0.99)	0.0003
Jaccard Coefficient	0.92 (0.89–0.94)	0.97 (0.95–0.98)	0.0002
Boundary F1 Score	0.68 (0.49–0.76)	0.96 (0.92–0.99)	$<0.0001$
	Inter-rater
	Manual	Guided	P-value
Dice Coefficient	0.92 (0.89–0.95)	0.96 (0.94–0.97)	$<0.0001$
Jaccard Coefficient	0.84 (0.81–0.90)	0.92 (0.89–0.93)	$<0.0001$
Boundary F1 Score	0.37 (0.19–0.55)	0.91 (0.82–0.94)	$<0.0001$