Table 3.
DMRs identified between CVS and PL DNA samples
| No. of DMRs | % CVS versus PL | |||||
|---|---|---|---|---|---|---|
| CHR | No. of HYPER in CVS | No. of HYPO in CVS | Total no. | % HYPER in CVS | % HYPO in CVS | % whole genome |
| chr1 | 587 | 177 | 764 | 9·30 | 9·96 | 9·44 |
| chr2 | 528 | 163 | 691 | 8·36 | 9·17 | 8·54 |
| chr3 | 310 | 99 | 409 | 4·91 | 5·57 | 5·05 |
| chr4 | 200 | 65 | 265 | 3·17 | 3·66 | 3·28 |
| chr5 | 286 | 116 | 402 | 4·53 | 6·52 | 4·97 |
| chr6 | 412 | 153 | 565 | 6·53 | 8·61 | 6·98 |
| chr7 | 311 | 66 | 377 | 4·93 | 3·71 | 4·66 |
| chr8 | 238 | 90 | 328 | 3·77 | 5·06 | 4·05 |
| chr9 | 146 | 34 | 180 | 2·31 | 1·91 | 2·22 |
| chr10 | 368 | 95 | 463 | 5·83 | 5·34 | 5·72 |
| chr11 | 204 | 123 | 327 | 3·23 | 6·92 | 4·04 |
| chr12 | 366 | 105 | 471 | 5·80 | 5·91 | 5·82 |
| chr13 | 168 | 79 | 247 | 2·66 | 4·44 | 3·05 |
| chr14 | 300 | 80 | 380 | 4·75 | 4·50 | 4·70 |
| chr15 | 282 | 84 | 366 | 4·47 | 4·72 | 4·52 |
| chr16 | 237 | 34 | 271 | 3·75 | 1·91 | 3·35 |
| chr17 | 378 | 33 | 411 | 5·99 | 1·86 | 5·08 |
| chr18 | 132 | 70 | 202 | 2·09 | 3·94 | 2·50 |
| chr19 | 215 | 21 | 236 | 3·41 | 1·18 | 2·92 |
| chr20 | 295 | 55 | 350 | 4·67 | 3·09 | 4·33 |
| chr21 | 160 | 26 | 186 | 2·53 | 1·46 | 2·30 |
| chr22 | 190 | 10 | 200 | 3·01 | 0·56 | 2·47 |
| Total | 6313 | 1778 | 8091 | |||
CHR: chromosome; CVS: chorionic villus sampling; DMR: differentially methylated region; HYPER: hypermethylated; HYPO: hypomethylated; PL: female nonpregnant plasma sample.