Table 3.
Power considerations under selected scenarios of λ magnitude, correction approach and effect size for uncommon variants and predetermined number of studies in meta-analysis.
| RLA | MLA | LLA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No correction | Single correction | Double correction | No correction | Single correction | Double correction | No correction | Single correction | Double correction | ||
| (n = 25 studies) | Power | Power | Power | Power | Power | Power | Power | Power | Power | |
| OR = 1·1 | MAF = 0·01 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| MAF = 0·03 | 0·25 | 0·13 | 0·1 | 0·1 | 0·03 | 0 | 0·17 | 0 | 0 | |
| OR = 1·2 | MAF = 0·01 | 0·39 | 0·19 | 0·13 | 0·43 | 0·14 | 0·04 | 0·39 | 0·04 | 0 |
| MAF = 0·03 | 33·2 | 28·58 | 23·93 | 33·81 | 20·71 | 10·67 | 32·52 | 8·95 | 0·81 | |
| OR = 1·3 | MAF = 0·01 | 9·26 | 7·43 | 5·77 | 9·53 | 4·38 | 1·74 | 9·58 | 1·29 | 0·04 |
| MAF = 0·03 | 96·85 | 95·74 | 94·01 | 97·12 | 92·89 | 85·55 | 96·94 | 83·54 | 47·98 | |
| OR = 1·4 | MAF = 0·01 | 48·48 | 42·89 | 37·33 | 49·4 | 33·38 | 19·02 | 48·41 | 16·56 | 2·4 |
| MAF = 0·03 | 100 | 100 | 99·99 | 100 | 99·96 | 99·94 | 99·98 | 99·88 | 98·14 | |