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. 2019 Nov 12;25:8515–8526. doi: 10.12659/MSM.920190

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© Med Sci Monit, 2019

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Methamphetamine induce elevation and MCC950 induce descend of NLRP3 inflammasome (NLRP3, Caspase-1 and ASC) and IL-1β, IL-18. (A) The Western Blot of NLRP3 inflammasome (NLRP3, Caspase-1 and ASC) and IL-1β, IL-18 of IEC-6 Cells of each group (Control, METH and METH+MCC950). (B) The q-PCR of NLRP3 inflammasome (NLRP3, Caspase-1 and ASC) and IL-1β, IL-18 of IEC-6 Cells of each group (Control, METH and METH+MCC950). (C) The Western Blot of NLRP3 inflammasome (NLRP3, Caspase-1 and ASC) and IL-1β, IL-18 of mice intestinal cells of each group (Control, NS, METH and METH+MCC950). (D) The q-PCR of NLRP3 inflammasome (NLRP3, Caspase-1 and ASC) and IL-1β, IL-18 of mice intestinal cells of each group (Control, NS, METH and METH+MCC950). β-actin was used as a loading control. * P<0.05 compared with that of Control group. ^# P<0.05 compared with that of METH group.